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Can you just stop taking levothyroxine? If you stop taking levothyroxine your symptoms are likely to come back. High doses of levothyroxine over a long time can sometimes cause weakening of the bones (osteoporosis). This shouldn't happen if you are on the right dose. It's important to have regular blood tests to make sure your dose isn't too high. Can taking levothyroxine cause weight gain? Weight Gain on Thyroxine. If there is one thing most doctors think they know it's that weight gain can be caused by an underactive thyroid and having an overactive thyroid leads to weight loss. So the thyroid hormone, thyroxine, will lead to weight loss. How long does it take for unithroid to work? The peak therapeutic effect of a given dose of Unithroid may not be attained for 4 to 6 weeks.
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