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What is the strongest antibiotic for acne? Isotretinoin is a powerful drug that's used to treat the most severe cases of acne. Which acne medication works best? Nonprescription Treatment for Acne Benzoyl peroxide. Sulfur. Topical clindamycin and erythromycin are antibiotics that are also anti-inflammatory drugs and are effective against a number of bacteria. For severe cystic acne, isotretinoin is the most effective therapy. What do dermatologists prescribe for cystic acne? Doctors agree, however, that by far the best cystic acne treatment is isotretinoin (i.e. Accutane), an oral form of vitamin A that targets all the sources of cystic acne by killing acne-causing bacteria, unclogging pores and cutting back on excess oil and inflammation. Should you pop pimples when they are white? While you can sometimes gently extract a whitehead, there are certain types of pimples you should never try to pop. Any red pimple without a white head (called papules) should not be squeezed. Those big, inflamed, deep blemishes (nodular breakouts and cysts) should never be squeezed, either. Will cystic acne go away on its own? There is, however, a certain skin condition that doesn't go away on its own and can last for (painful) weeks: cystic acne. "Most tend to treat cysts as they would a standard blemish, which will only serve to further irritate already-sensitive skin," she notes.
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